Abstract #2392

MM-suppressed GABA measurements are highly susceptible to B0 field instability

Richard Anthony Edward Edden^1,2, Ashley D. Harris^1,2,3,4, Nicolaas Puts^1,2, Kimberly L. Chan^1,2,5, Michael Schar¹, and Peter B. Barker^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁴Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, ⁵Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, United States

J-difference-edited measurements of GABA are usually contaminated up to 50% by macromolecular (MM) signal. It is possible to suppress this signal using a symmetrical editing motif, which relies upon partially inverting the MM signals to an equal degree in the two halves of the edited experiment. In the event of B₀ field offset, the symmetry breaks down and either positive or negative MM signal rapidly contaminates the measured GABA signal. Here, we investigate this issue using simulations and in vivo experiments.

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