Hao Shu1, Guangyu Chen1, Gang Chen1, B. Douglas Ward1, Piero G. Antuono2, and Shi-Jiang Li1
1Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, United States
Aging
and the apolipoprotein E (APOE) ε4 allele are two established factors advancing
Alzheimer’s disease (AD) progression; however, the extent to which these factors
effect AD remains unclear. In this
study, we employed the event-based probabilistic model to develop an index for characterizing
Alzheimer’s disease risk event (CARE); we then used the CARE index to quantify the
effects of age and the APOE ε4 allele on AD
progression. This study demonstrated an aging-related increase in CARE index scores and its
exacerbation by the APOE ε4 allele, thus providing a surrogate
to quantitatively assess aging and the APOE ε4 allele modulations on
AD progression.
