The population of Alzheimer's
disease (AD) is increasing due to increased longevity in human. The dementing condition associated with AD is
reported to be more in female than male. In this study, we explored the
neurotransmitter metabolism in APP-PS1 female mice, and compared with age
matched males, using 1H-[13C]-NMR spectroscopy following
an administration of [1,6-13C2]glucose. The cerebral metabolic rates of glucose oxidation by
glutamatergic and GABAergic neurons was found to be reduced in the cerebral
cortex, striatum and hippocampus of the transgenic male mice. In contrary,
transgenic female mice did not show change in metabolic rates when compared
with wild type controls.
