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Abstract #1271

Profiling patterns of white matter injury in normal pressure hydrocephalus pre- and post-intervention using diffusion tensor imaging

Nicole Chwee Har Keong1,2, Alonso Pena3, Stephen J Price4, Marek Czosnyka4, Zofia Czosnyka4, Elise DeVito5, Charlotte Housden6, Jonathan H Gillard7, Barbara Sahakian6, and John D Pickard4

1Neurosurgery, National Neuroscience Institute, Singapore, Singapore, 2Neurosurgery, University of Cambridge, Cambridge, United Kingdom, 3SDA Bocconi School of Management, Milan, Italy, 4Neurosurgical Division, Dept of Clinical Neurosciences, University of Cambridge Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 5Dept of Psychiatry, Yale University School of Medicine, New Haven, CT, United States, 6Department of Psychiatry and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom, 7Department of Radiology, University of Cambridge, Cambridge, United Kingdom

Normal pressure hydrocephalus (NPH) is a confounding condition of gait disturbance, cognitive decline and urinary incontinence remediable with surgical intervention. We have used diffusion tensor imaging (DTI) to demonstrate patterns of white matter injury pre- and post-surgical intervention

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