Abstract #1234

Increased slow diffusion in cortical gray matter is related with cognitive decline in severe white matter hyperintensity

Yerfan Jiaerken¹, Xinfeng Yu¹, and Minming Zhang¹

¹Radiology, The second affiliated hospital of Zhejiang university school of medicine, Hangzhou, China, People's Republic of

We used MRI IVIM technique to investigate how is microstructure in cortical gray matter (CGM) affected by white matter hyperintensity (WMH), and how does it affect cognitive function. We found that diffusion in WMH is correlated with diffusion in CGM. And diffusion in CGM is connected with cognitive state, while diffusion in WMH isn’t. This may suggest that CGM damage is secondary to microstructural damage in WMH. And CGM damage may lead to cognitive dysfunction， while WMH can only affect cognitive state by damaging gray matter.

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