João M.N. Duarte1, Blanca Lizarbe1, Rolf Gruetter1,2,3, and Ana Francisca Soares1
1LIFMET, EPFL, Lausanne, Switzerland, 2UNIL, Lausanne, Switzerland, 3UNIGE, Geneva, Switzerland
Insulin resistance
has deleterious effects on memory performance, brain morphology and
the neurochemical profile of the cortex and hippocampus. We now investigated
the neurochemical modifications in the hippocampus, cortex and hypothalamus of
mice exposed to high-fat diet, a model of obesity-associated insulin resistance.
In long-term high-fat diet-exposed mice, obesity-associated insulin resistance affects the
neurochemical profiles of the hippocampus, cortex and hypothalamus in a
region-specific manner.
