Abstract #1233

Regeneration of olfactory performance after sinus surgery correlates with white matter changes in cingulum bundle

Daniel Güllmar¹, Tabea Witting², Thomas Bitter², Orlando Guntinas-Lichius², and Jürgen R Reichenbach¹

¹Medical Physics Group / IDIR, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ²Department of Otolaryngology and the Institute of Phoniatry and Pedaudiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

In this study we have investigated neuronal changes in a longitudinal study using anatomical and structural MRI before and after pansinus surgery. Neuronal changes measured by means of DTI before and after surgery were compared to changes in olfactory performance. The analysis was carried out using a tract specific analysis involving probabilistic tractography and subsequent alignment of control points along the cingulum bundles. Patients, which showed an improvement >10 in olfactory performance measure, showed also a significant increase in radial diffusivity in the middle segment of the left cingulum bundle.

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