Xiaowei Zhuang1, Zhengshi Yang1, Tim Curran2, and Dietmar Cordes1,2
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States
In
this abstract, the input/output transfer relationship in human hippocampal
subfields (mainly CA1, CA3, and DG) was studied using fMRI during a spatial
memory task with increments in the change of FOV in the stimuli. Whole brain
activation was obtained for all lure v/s control contrasts. Mean activation t
value for each hippocampal subregions (CA1, CA2&3 and CA4&DG) was
extracted, averaged over all the subjects and plotted against FOV changes to
compare with the existing models. K-means clustering was then applied. Data
from one of the k-means clusters showed a pattern separation/completion curve
similar to the animal model.
