Abstract #0484

Deciphering the Functional Connectome of the External Globus Pallidus with Electrical and Optogenetic Deep Brain Stimulation-fMRI

Daniel Albaugh¹, Nathalie Van Den Berge², Andrew Salzwedel³, Wei Gao³, Garret Stuber⁴, and Yen-Yu Ian Shih⁵

¹Curriculum in Neurobiology, UNC-Chapel Hill, Chapel Hill, NC, United States, ²University of Ghent, Ghent, Belgium, ³Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Psychiatry, UNC-Chapel Hill, Chapel Hill, NC, United States, ⁵Biomedical Research Imaging Center, UNC-Chapel Hill, Chapel Hill, NC, United States

In this study, we unraveled the circuit and network connectivity of the rodent external globus pallidus (GPe), both in the healthy animals and a parkinson's disease model. We also employed multiple stimulation types (electrical and optogenetic), as well as fMRI modalities (evoked-fMRI and functional connectivity analyses) to provide an exhaustive analysis of this dynamic brain nucleus.

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