Dissociated longitudinal patterns of neural activation, functional connectivity and structural connectivity in a mouse model of de- and re-myelination
Yi-Ching Lynn Ho1,2, Fiftarina Puspitasari1, Way-Cherng Chen1, and Kai-Hsiang Chuang1
1Singapore Bioimaging Consortium, Agency for Science, Technology & Research (A*STAR), Singapore, Singapore, 2Interdisciplinary Institute of Neuroscience & Technology (ZIINT), Zhejiang University, Hangzhou, China, People's Republic of
We
hypothesized that structure and functional responses do not demonstrate the
same pattern of impairment across time. Using the cuprizone mouse model of
reversible demyelination, we show different longitudinal patterns of neural
activation and functional connectivity, compared to healthy mice and also to the
extent of cuprizone demyelination.
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