Abstract #0244

Hyperpolarized 13C MRSI can detect neuroinflammation in vivo in a Multiple Sclerosis murine model

Caroline Guglielmetti^1,2, Chloe Najac¹, Annemie Van der Linden², Sabrina M Ronen¹, and Myriam M Chaumeil¹

¹University of California San Francisco, San Francisco, CA, United States, ²University of Antwerp, Antwerp, Belgium

This study demonstrates that¹³C MRS of hyperpolarized pyruvate can be used to detect increased lactate production from pro-inflammatory macrophages, mechanism mediated by pyruvate dehydrogenase kinase-1 upregulation and pyruvate dehydrogenase inhibition, in a preclinical model of multiple sclerosis, hence providing a novel tool for in-vivo detection of neuroinflammation.

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