Abstract #0242

Quantitative Susceptibility Mapping (QSM) in patients with clinically isolated syndrome (CIS) and multiple sclerosis (MS) - a large cohort study

Ferdinand Schweser^1,2, Jesper Hagemeier¹, Paul Polak¹, Michael G Dwyer¹, Niels P Bergsland^1,3, Nicola Bertolino¹, Bianca Weinstock-Guttman⁴, Andreas Deistung⁵, Jürgen R Reichenbach^5,6, and Robert Zivadinov^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ²MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ³MR Research Laboratory, IRCCS Don Gnocchi Foundation ONLUS, Milan, Italy, ⁴Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ⁵Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ⁶Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany

Quantitative susceptibility mapping (QSM) is the most sensitive technique available for studying tissue iron in vivo. In this work, we applied QSM to more than 1000 patients with multiple sclerosis (MS) and almost 250 patients with clinically isolated syndrome (CIS). Our results provide strong support for changed deep gray matter iron concentrations in MS and CIS.

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