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Abstract #4711

In-vivo detection of dopamine in the substantia nigra using 3D MRSI

Adriane Grger 1,2 , Rupert Kolb 2 , and Uwe Klose 2

1 Department of Neurology and Neuroimaging Center (NIC), Mainz, Germany, 2 Department of Diagnostic and Interventional Neuroradiology, Magnetic Resonance Research Group, Tbingen, Germany

Progressive degeneration of dopamine-producing neurons within the substantia nigra pars compacta in Parkinson's disease may be caused by mitochondrial dysfunction and oxidative stress which can also explain our MRSI findings of reduced NAA, creatine, glutathione and dopamine as well as elevated taurine, GABA and glutamate in the region of the substantia nigra.

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