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Abstract #4710

Characterization of water transportation via aquaporin using tri-exponential model in cerebral infarction and Parkinson's disease - preliminary study

Xueying Ling 1 , Zhongping Zhang 2 , Zhoushe Zhao 2 , Lian Huang 3 , Yusheng Zhang 4 , Li Guo 5 , Yongjin Shi 6 , Changzheng Shi 6 , Li Huang 6 , and Hao Xu 6

1 medical imaging center, the first affiliated hospital of Jinan university, Guangzhou, Guangdong, China, 2 GE healthcare, China, Guangdong, China, 3 neurology, the first affiliated hospital of Jinan university, Guangzhou, Guangdong, China, 4 neurology, the first affiliated hospital of Jinan university, Guangdong, China, 5 the first affiliated hospital of Jinan university, Guangdong, China, 6 medical imaging center, the first affiliated hospital of Jinan university, Guangdong, China

In biologic tissues, water molecules motion mainly includes perfusion in the capillary network, diffusion in the extracellular space, and the permeation in the membrane by aquaporins. A triexponetial model based on multiple b-value diffusion weighted imaging (mbDWI) has theoretical advantages over currently available water diffusion measurements. Because it is intrinsically quantitative, and is mainly dependent on three components hypothesis, i.e. capillary flow (fast component), pure water diffusion (intermediate component) and high b-value related diffusion (slow component probably by aquaporins in the membrane).

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