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Abstract #4712

Putamen radial diffusivity is an independent predictor of prion disease severity

Harpreet Hyare 1 , Enrico De Vita 2 , Marie-Claire Porter 1 , Ivor Simpson 1 , Ged Ridgway 1 , Simon Mead 1 , Peter Rudge 1 , John Collinge 1 , Sebastien Ourselin 3 , and John Thornton 2

1 Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom, 2 Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 3 Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom

As we enter the era of therapeutic trials in human prion diseases, identification of imaging secondary endpoints is paramount. We present the largest comprehensive cross-sectional and longitudinal findings of microstructural changes in a heterogenous group of patients with human prion disease and argue that radial diffusivity in the putamen is an independent predictor of disease severity and a potential secondary endpoint in future clinical trials in this disease.

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