Abstract #4712
Putamen radial diffusivity is an independent predictor of prion disease severity
Harpreet Hyare 1 , Enrico De Vita 2 , Marie-Claire Porter 1 , Ivor Simpson 1 , Ged Ridgway 1 , Simon Mead 1 , Peter Rudge 1 , John Collinge 1 , Sebastien Ourselin 3 , and John Thornton 2
1
Department of Neurodegenerative Diseases,
UCL Institute of Neurology, London, United Kingdom,
2
Lysholm
Department of Neuroradiology, National Hospital for
Neurology and Neurosurgery, London, United Kingdom,
3
Centre
for Medical Image Computing (CMIC), University College
London, London, United Kingdom
As we enter the era of therapeutic trials in human prion
diseases, identification of imaging secondary endpoints
is paramount. We present the largest comprehensive
cross-sectional and longitudinal findings of
microstructural changes in a heterogenous group of
patients with human prion disease and argue that radial
diffusivity in the putamen is an independent predictor
of disease severity and a potential secondary endpoint
in future clinical trials in this disease.
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