Abstract #4687
Establishing a reference of iron deposition in human brain deep grey matter nuclei using susceptibility mapping
Manju Liu 1 , Saifeng Liu 2 , Dane Dicicco 3 , Charbel Habib 4 , Yanwei Miao 5 , and E. Mark Haacke 1,3
1
Department of Biomedical Engineering, Wayne
State University, Detroit, MI, United States,
2
School
of Biomedical Engineering, McMaster University,
Hamilton, Ontario, Canada,
3
The
MRI Institute for Biomedical Research, Detroit, MI,
United States,
4
Department
of Radiology, Wayne State University, Detroit, MI,
United States,
5
Department
of Radiology, The First Affiliated Hospital, Dalian,
Liaoning, China
Iron is a vital element for human brains to function
properly. Iron overload or deficiencies is harmful to
the brain. This study focuses on establishing the brain
iron deposition reference in healthy people using
magnetic susceptibility mapping (SWIM), which is
generated from Susceptibility-Weighted Imaging (SWI)
phase images. We recruited 180 normal subjects, and the
3D volume of 7 brain nuclei were analyzed. The results
show iron content increases with age in Putamen, Red
Nucleus and Caudate Nucleus. The iron changing pattern
in our study is consistent with Hallgren and Souranders
work, which was performed on the post mortem human
brains.
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