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Abstract #4687

Establishing a reference of iron deposition in human brain deep grey matter nuclei using susceptibility mapping

Manju Liu 1 , Saifeng Liu 2 , Dane Dicicco 3 , Charbel Habib 4 , Yanwei Miao 5 , and E. Mark Haacke 1,3

1 Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, 2 School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada, 3 The MRI Institute for Biomedical Research, Detroit, MI, United States, 4 Department of Radiology, Wayne State University, Detroit, MI, United States, 5 Department of Radiology, The First Affiliated Hospital, Dalian, Liaoning, China

Iron is a vital element for human brains to function properly. Iron overload or deficiencies is harmful to the brain. This study focuses on establishing the brain iron deposition reference in healthy people using magnetic susceptibility mapping (SWIM), which is generated from Susceptibility-Weighted Imaging (SWI) phase images. We recruited 180 normal subjects, and the 3D volume of 7 brain nuclei were analyzed. The results show iron content increases with age in Putamen, Red Nucleus and Caudate Nucleus. The iron changing pattern in our study is consistent with Hallgren and Souranders work, which was performed on the post mortem human brains.

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