Meeting Banner
Abstract #4686

Aging in Deep Gray Matter Revealed by Diffusional Kurtosis Imaging

Nan-Jie Gong 1,2 , Chun-Sing Wong 1 , Chun-Chung Chan 3 , Lam-Ming Leung 4 , Yiu-Ching Chu 5 , and Queenie Chan 6

1 Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, 2 Radiology, Stanford University, Stanford, CA, United States, 3 Geriatrics & Medicine, United Christian Hospital, Hong Kong, China, 4 Psychiatry, United Christian Hospital, Hong Kong, China, 5 Radiology, Kwong Wah Hospital, Hong Kong, China, 6 Philips Healthcare, Hong Kong, China

we utilised DKI method in both deep gray and white matters of normal aging adults. The results suggested that diffusional kurtosis can provide measurements in a new dimension complementary to those of diffusivity metrics. Kurtosis together with diffusivity can more comprehensively characterize microstructural compositions and age-related changes than diffusivity alone. In terms of deep gray matter, higher MK and FA in the globus pallidus, substantia nigra and red nucleus mirrored the higher microstructural complexity and directionality compared to putamen, caudate nucleus and thalamus. In particular, we proposed that the unique age-related increasing of FA, MK and KR in the putamen may be resulted from iron deposition.

This abstract and the presentation materials are available to members only; a login is required.

Join Here