Abstract #4688
Age and Gender - Related Changes in the Normal Human Brain Using Hybrid Diffusion Imaging (HYDI) with Neurite Orientation Dispersion and Density Imaging (NODDI) Analysis
Chandana Kodiweera 1 , Andrew K Alexander 2 , and Yu-Chien Wu 1
1
Psychological and Brain Sciences, Dartmouth
College, Hanover, New Hampshire, United States,
2
Department
of Medical Physics, University of Wisconsin School of
Medicine and Public Health, Madison, Wisconsin, United
States
To better characterize the findings of
diffusion-weighted imaging with underlying biological
and pathological changes of the human brain, several
multiple-compartments diffusion models were proposed
recently. In this study, we used Hybrid Diffusion
Imaging (HYDI), a 5-shells diffusion-encoding scheme,
with Neurite Orientation and Density Imaging (NODDI)
data analysis. Fifty-two subjects aged from 18 to 72
years were studied. We found that the orientation
dispersion index increases as age increases suggesting
that the white matter organization loses coherence over
age. While WM organization seems to be more sensitive
with normal aging, the overall intracellular volume
fraction remains stable over the aging course.
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