Abstract #4656
Differentiating neural and vascular effects of caffeine in resting state connectivity study
Yongquan Ye 1 and E. Mark Haacke 1,2
1
Radiology, Wayne State University, Detroit,
Michigan, United States,
2
Biomedical
Engineering, Wayne State University, Detroit, Michigan,
United States
Caffeine is known to modify both the levels of cerebral
persuion and alertness, affecting the resting state
connectivity results. Existing studies have demonstrated
that the induced connectivity changes are mainly the
result of neural stimluation, the role and ratio effect
of the perfusion part is yet to be explored. We use flow
dephasing dark blood method the aquire resting state
data and compare them between normal BOLD data under the
pre- and post-caffeine intake conditions. We found that
reduction in perfusion during caffeine intake may
actually account for a greater effect than expected, and
is opposite to caffeine's neural enhancement effects.
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