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Abstract #4655

Cerebral blood flow, vascular reactivity and oxygen consumption in healthy aging.

J. B. De Vis 1 , E. T. Petersen 1 , A. Bhogal 1 , L. J. Kappelle 2 , and J. Hendrikse 1

1 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Neurology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

Previous studies have found conflicting results when it comes to age-related changes in brain hemodynamic parameters. The purpose of this study was to investigate the influence of age on brain hemodynamics. For this purpose, calibrated MRI was performed in a group of young healthy subjects and a group of elderly healthy subjects. We found lower whole brain and regional cerebral blood flow, oxygen extraction fraction and oxygen consumption in the elderly subjects compared to the young subjects.

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