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Abstract #4654

Effects of Propofol Anesthesia and Sex on Cerebral Blood Flow

Pelin Aksit Ciris 1 , Maolin Qiu 2 , and R. Todd Constable 3

1 Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2 Diagnostic Radiology, Yale University, School of Medicine, New Haven, CT, United States, 3 Diagnostic Radiology, Neurosurgery, and Biomedical Engineering, Yale University, School of Medicine, New Haven, CT, United States

We present whole brain quantification of Cerebral Blood Flow at rest and during Propofol administration across a cohort of 32 normal male and female subjects, and the highlight significant differential effects of sex and anesthesia. Our findings were in good agreement with the limited available literature. Such variations should be considered in the interpretation of perfusion or fMRI studies conducted under anesthesia. Improved understanding of the mechanisms underlying these differences, could lead to more specific models of cerebrovascular responses, improved assessment of anesthetic requirements and better management of anesthesia in all patients.

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