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Abstract #4657

Effects of hormonal contraception on the default mode network: a resting-state MRI study

Timo De Bondt 1 , Dirk Smeets 2 , Wim Van Hecke 2 , Yves Jacquemyn 3 , and Paul M Parizel 1

1 Radiology, Antwerp University Hospital, Antwerp, Antwerp, Belgium, 2 icoMetrix, Leuven, Belgium, 3 Gynaecology and Obstaetrics, Antwerp University Hospital, Antwerp, Belgium

It is well established that sex differences occur in brain structure and function, which result in behavioral dissimilarities. However, only in recent years, the effect of menstrual cycle phase and hormonal contraceptives has been considered. In this research we used spatially constrained independent component analysis to infer differences in resting state BOLD response of the default mode network in a healthy population of young women. When comparing natural cycle (NC) group with hormonal contraceptives (HC) group, results show a decreased activity in the posterior cingulate cortex in the HC group.

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