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Abstract #4601

Dual Compartmental Fitting of Dynamic Susceptibility Contrast MRI in Early Ischemic Stroke

M. Ethan MacDonald 1,2 , Estee Lee 1,2 , Ting Lee 2,3 , Jordan Woehr 4 , Chris d'Esterre 2,5 , Michael R Smith 4,5 , and Richard Frayne 2,5

1 Biomedical Engineering, University of Calgary, Calgary, AB, Canada, 2 Seaman Family Magnetic Resonance Research Centre, Hotchkiss Brain Institute, Foothills Medical Centre, Calgary, AB, Canada, 3 Imaging Research Labs, Robarts Research Institute, London, ON, Canada, 4 Electrical & Computer Engineering, University of Calgary, Calgary, AB, Canada, 5 Radiology & Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

In this work we use dynamic susceptibility contrast MR imaging and fit a duel compartmental model to the residue function. The proposed duel compartmental model has been used in CT perfusion with great success, consisting of a rectangular function and exponential decay. The model is interactively fit to the residue function with an iterative least squares conjugate gradient algorithm. Parametric maps and goodness of fit maps were produced for an acute ischemic stroke patient. Fit quality is high in regions of normal flow, but where flow is low, <10 ml/100 g/min, the quality of the fit is diminished.

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