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Abstract #4600

Tau b : A Metabolic Neuroimaging Biomarker

William D. Rooney 1 , Xin Li 1 , John W. Grinstead 2 , Edward A. Neuwelt 3 , and Charles S. Springer, Jr. 1

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, 2 Siemens Healthcare, Portland, Oregon, United States, 3 Blood-Brain-Barrier Program, Oregon Health & Science University, Portland, Oregon, United States

Monomeric Gd(III) chelate contrast agents (CA) do not extravasate in normal brain. In that case, shutter-speed pharmacokinetic analysis of DCE-MRI data allows mapping of the mean capillary water lifetime, tau b . The magnitude of this biomarker is inversely proportional to neuronal Na + /K + ATPase [NKA] activity. However, in glioblastoma multiforme brain tumors these CAs extravasate rapidly. Here, we use an intravascular SPIO CA, Ferumoxytol, which does not extravasate during the study. It reveals that tumor tau b is dramatically elevated: NKA activity is drastically reduced.

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