Abstract #4600
Tau b : A Metabolic Neuroimaging Biomarker
William D. Rooney 1 , Xin Li 1 , John W. Grinstead 2 , Edward A. Neuwelt 3 , and Charles S. Springer, Jr. 1
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Siemens
Healthcare, Portland, Oregon, United States,
3
Blood-Brain-Barrier
Program, Oregon Health & Science University, Portland,
Oregon, United States
Monomeric Gd(III) chelate contrast agents (CA) do not
extravasate in normal brain. In that case, shutter-speed
pharmacokinetic analysis of DCE-MRI data allows mapping
of the mean capillary water lifetime, tau
b
.
The magnitude of this biomarker is inversely
proportional to neuronal Na
+
/K
+
ATPase
[NKA] activity. However, in glioblastoma multiforme
brain tumors these CAs extravasate rapidly. Here, we use
an intravascular SPIO CA, Ferumoxytol, which does not
extravasate during the study. It reveals that tumor tau
b
is
dramatically elevated: NKA activity is drastically
reduced.
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