Meeting Banner
Abstract #4602

Extravascular extracellular space fraction measurement by DSC-MRI: a theoretical study

Yikang Liu 1 , Weiping Ding 1 , and Bensheng Qiu 1

1 Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui, China

The unclear T1 and T2* effect dominance caused by contrast agent (CA) leakage makes the explanation of Capital Greek Delta R2* curve difficult. However, through a numeric simulation where cells and vessels were randomly distributed while EES fraction and vascular permeability controlled, a linear relationship between EES fraction and ratio of the two parameters K1 and K2 in Weisskoff model has been demonstrated, which on the other hand varied little with vascular permeability. As a consequence, a potential approach to measure relative Ve by DSC-MRI is feasible and clinical data is expected to prove the theory.

This abstract and the presentation materials are available to members only; a login is required.

Join Here