Abstract #4595
Implications of unequal interstitium and plasma contrast reagent relaxivities in pharmacokinetic analysis of DCE-MRI
Xin Li 1 , Yu Cai 1 , Brendan Moloney 1 , Wei Huang 1 , Mark G. Garzotto 2,3 , Mark Woods 1 , and Charles S Springer 1
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Portland
VA Medical Center, Portland, Oregon, United States,
3
Urology,
Oregon Health & Science University, Portland, Oregon,
United States
In Dynamic Contrast Enhanced Magnetic Resonance Imaging
(DCE-MRI), contrast reagent (CR) concentration is
linearly related to water R1 change for a single
compartment. The longitudinal relaxivity quantifies the
CR potency to change water proton T1. It is current
practice to assume that the longitudinal relaxivities
are the same in blood plasma and all interstitial
compartments. However, there is evidence suggesting a
potential increase in the interstitium longitudinal
relaxivity. Based on human prostate data, we demonstrate
the implications of unequal interstitium and plasma
relaxivity values on DCE-MRI pharmacokinetic parameters.
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