Abstract #4596
Quantification of macromolecular albumin-Gd-DTPA contrast using 3D cardiac T1 mapping in normal myocardium
Vandoorne Katrien 1 , Moriel H Vandsburger 2 , Hagit Dafni 3 , Michal Neeman 4 , Gustav J Strijkers 1 , and Klaas Nicolay 1
1
Biomedical NMR, Biomedical Engineering,
Eindhoven University of Technology, Eindhoven,
Netherlands,
2
Physiology,
University of Kentucky, Lexington, Kentucky, United
States,
3
Veterinary
Resources, Weizmann Institute of Science, Rehovot,
Israel,
4
Biological
Regulation, Weizmann Institute of Science, Rehovot,
Israel
This pilot study aimed to develop a method to quantify
the dynamics of a blood pool contrast agent for mapping
the myocardial microvascular density and the rate of
extravasation from blood vessels at the myocardium using
in vivo dynamic contrast enhanced (DCE) MRI. Therefore,
we quantify the characteristics and dynamics of the
macromolecular contrast agent in blood vessels of
control murine myocardium. In the future, this method
could be used to quantify permeability in diseased
myocardium. Therefore, this method using high-molecular
weight contrast agent might allow quantification of
permeability in the future and has the potential to
determine disease progression.
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