Abstract #4594
Bolus Arrival Time extraction using Super Temporal Resolution Analysis of DCE
Gilad Liberman 1,2 , Guy Nadav 1,3 , Yoram Louzoun 2,4 , Moran Artzi 1,5 , and Dafna Ben Bashat 1,5
1
Functional Brain Center, Tel Aviv Sourasky
Medical Center, Tel Aviv, Israel,
2
Gonda
Multidisciplinary Brain Research Center, Bar Ilan
University, Ramat Gan, Israel,
3
School
of Electrical Engineering, Tel Aviv University, Tel
Aviv, Israel,
4
Mathematics
Department, Bar Ilan University, Ramat Gan, Israel,
5
Sackler
Faculty of Medicine and Sagol School of Neuroscience,
Tel Aviv University, Tel Aviv, Israel
DCE is commonly acquired in a temporal-resolution of
~6sec, lower than inter-tissue differences (~1-3sec).
This study proposes a super temporal-resolution analysis
method for DCE, based on the Extended-Tofts Model (ETM)
by including a delay accounting for the bolus
arrival-time (BAT). The method was (1) tested on
simulations (2) tested on data from patients with brain
tumors, acquired with high(~2sec) and standard
temporal-resolution and (3) BAT values were compared
with DSC-TTP values. This study shows that accounting
for the delay in DCE analysis, can result in a better
AIF estimation and provides additional important
parameter relating to the tissue vasculature.
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