Meeting Banner
Abstract #4420

Mathematical models of colorectal tumour microstructure informed by oscillating gradients diffusion MRI

Alessandro Proverbio 1 , Bernard M. Siow 2,3 , Eleftheria Panagiotaki 3 , Samuel Walker-Samuel 2 , Mark F. Lythgoe 2 , Adam P. Gibson 1 , and Daniel C. Alexander 3

1 Medical Physics and Bioengineering, University College London, London, United Kingdom, 2 Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, 3 Centre for Medical Image Computing and Department of Computer Science, University College London, London, United Kingdom

Investigation of tissue microstructure with non-invasive histology is a developing research area. Diffusion MRI (dMRI) can estimate features of microstructural components such as cell cytoarchitecture. Here develop signal models for Square Wave Oscillating Gradient Spin Echo (SWOGSE) dMRI. This study is performed on fixed subcutaneous xenograft tumour samples grown in nude mice: 3 LS174T, and 3 SW1222 cell lines. Oscillating Gradient Spin Echo probes shorter length scales than standard PGSE. The more tissue-like compartment model appears to represent the signal better, suggesting the feasibility of a clinical measurement of cytological properties of the tissue.

This abstract and the presentation materials are available to members only; a login is required.

Join Here