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Abstract #4419

NMR characterization of cylinder radii distributions using a SHORE-based regularization method

Gonzalo Sanguinetti 1 , Matt G Hall 2 , Daniel C Alexander 2 , and Rachid Deriche 1

1 Athena Project-Team, INRIA, Sophia-Antipolis, France, 2 Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom

We are interested in retrieving information about the axon diameter distributions in white matter fiber bundles using NMR, which are commonly modelled as ensembles of parallel cylinders. We add regularization to the 1D-SHORE basis which results in more stable characterization of diameter distributions. To validate the method, we simulate NMR signals using the open source toolkit CAMINO. The results illustrate the enhanced estimation accuracy given by the regularization and provide an alternative validation of the SHORE based method.

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