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Abstract #4418

Axon diameter distribution (ADD) mapping of porcine spinal cord using d-PFG MRI

Dan Benjamini 1,2 , Michal E Komlosh 1,3 , Uri Nevo 2 , and Peter J Basser 1

1 NIH, Bethesda, MD, United States, 2 Tel Aviv University, Tel Aviv, Israel, 3 USUHS, Bethesda, MD, United States

Noninvasive estimation of a non-parametric axon diameter distribution (ADD) provides sub-voxel microstructural information of white matter tissue. ADD infers on the nerve conductivity, and is influenced by several diseases, such as amyotrophic lateral sclerosis and multiple sclerosis. A recently suggested 2D double pulsed-field gradient MRI experiment is used on a porcine spinal cord. A voxel-by-voxel non-parametric ADD estimation provides a sub-voxel resolution map. Distinct domains where the ADDs are similar are then found. ADD estimation might prove to have clinical MRI applications owing to its critical functional role in the central and peripheral nervous systems, in normal and abnormal tissue.

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