Abstract #4417
Fast and robust measurement of microstructural dimensions using temporal diffusion spectroscopy
Hua Li 1 , John C. Gore 1 , and Junzhong Xu 1
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
Current PGSE-based approaches usually require long
scanning times and high q-values to detect small axons,
which are limited by the long diffusion times and the
significantly reduced sensitivity to small spatial
scales. OGSE has been shown to achieve much shorter
diffusion times and hence may be able to detect smaller
axons with high sensitivity. We measure the inner
diameters of hollow microcapillaries using OGSE methods.
Two ADC values are sufficient to extract the cylinder
diameters accurately. OGSE is insensitive to the
intrinsic diffusion coefficient in the relatively low
frequency range. We propose OGSE as a fast and robust
method for mapping axon sizes non-invasively.
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