Abstract #4212
Optimisation of acquisition time for a dual calibrated FMRI protocol to measure absolute CMRO 2
Alan J Stone 1 , Kevin Murphy 1 , Ashley D Harris 2,3 , and Richard G Wise 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, United Kingdom,
2
Russell
H. Morgan Department of Radiology and Radiological
Science, The Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States,
3
F.M.
Kirby Center for Functional Brain Imaging, Kennedy
Krieger Institute, Baltimore, Maryland, United States
To aid the implementation of dcFMRI in clinical and
research scan protocols, it is necessary to produce
reliable measures of absolute CMRO
2
in
a short scan time. However, reducing scan time must be
done carefully and it is important to establish that the
parameter measurements are not compromised. Here we
investigate reducing scan times of an interleaved and
simultaneous hypercapnic-hyperoxic dcFMRI acquisition
using two analytical approaches. A varying window
duration analysis is used to investigate if periods of
respiratory challenges can be shortened and a
data-point resampling analysis is used to investigate
if fewer respiratory challenges can be performed.
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