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Abstract #4212

Optimisation of acquisition time for a dual calibrated FMRI protocol to measure absolute CMRO 2

Alan J Stone 1 , Kevin Murphy 1 , Ashley D Harris 2,3 , and Richard G Wise 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2 Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 3 F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States

To aid the implementation of dcFMRI in clinical and research scan protocols, it is necessary to produce reliable measures of absolute CMRO 2 in a short scan time. However, reducing scan time must be done carefully and it is important to establish that the parameter measurements are not compromised. Here we investigate reducing scan times of an interleaved and simultaneous hypercapnic-hyperoxic dcFMRI acquisition using two analytical approaches. A varying window duration analysis is used to investigate if periods of respiratory challenges can be shortened and a data-point resampling analysis is used to investigate if fewer respiratory challenges can be performed.

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