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Abstract #4211

Using dual calibrated FMRI to detect CBF related changes in OEF during hyperventilation

Alan J Stone 1 , Kevin Murphy 1 , and Richard G Wise 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom

Dual calibrated FMRI (dcFMRI) is an extension of the calibrated BOLD methodology, capable of producing regional measurements of oxygen extraction fraction (OEF) across the brain. 6 normal healthy participants were scanned using a hypocapnic challenge to demonstrate the sensitivity of the dcFMRI technique to detect increases in OEF associated with reductions in CBF. The data acquired during normocapnia (baseline CBF) and hypocapnia (lowered CBF) shows a clear decrease in CBF and increase in OEF with hypocapnia. This demonstrates the sensitivity of dcFMRI suggesting the technique is appropriate for application to vascular dysfunction in which flow and metabolism may be impaired.

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