Abstract #4211
Using dual calibrated FMRI to detect CBF related changes in OEF during hyperventilation
Alan J Stone 1 , Kevin Murphy 1 , and Richard G Wise 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, United Kingdom
Dual calibrated FMRI (dcFMRI) is an extension of the
calibrated BOLD methodology, capable of producing
regional measurements of oxygen extraction fraction
(OEF) across the brain. 6 normal healthy participants
were scanned using a hypocapnic challenge to demonstrate
the sensitivity of the dcFMRI technique to detect
increases in OEF associated with reductions in CBF. The
data acquired during normocapnia (baseline CBF) and
hypocapnia (lowered CBF) shows a clear decrease in CBF
and increase in OEF with hypocapnia. This demonstrates
the sensitivity of dcFMRI suggesting the technique is
appropriate for application to vascular dysfunction in
which flow and metabolism may be impaired.
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