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Abstract #4213

Novel MRI indicators of cerebrovascular compliance in response to cardiac pressure wave

Marta Bianciardi 1 , Nicola Toschi 1,2 , Jonathan R Polimeni 1 , Himanshu Bhat 3 , Bruce R Rosen 1 , David A Boas 1 , and Lawrence L Wald 1

1 Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH, Harvard Medical School, Boston, MA, United States, 2 Department of Medicine, University of Rome Tor Vergata, Rome, Italy, 3 Siemens Medical Solutions, Boston, MA, United States

The aim of this work was to develop novel MRI-indicators that evaluate cerebrovascular compliance through direct measures of blood volume changes. We employed time-of-flight EPI-MRI, and constrained the sequence parameters to produce MRI-contrast dependent primarily on blood volume changes. A pulsatility-Volume-Index (pVI) was defined as the ratio of the signal during systole divided by the signal during diastole integrated within the vascular tree. pV1 was on average ~1.5 in larger cerebral arteries, and varied within each arterial segment and across arteries. pVI seems to be a promising MRI-indicator for the evaluation of cerebrovascular compliance in a highly localized and subject-specific-manner.

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