Abstract #4213
Novel MRI indicators of cerebrovascular compliance in response to cardiac pressure wave
Marta Bianciardi 1 , Nicola Toschi 1,2 , Jonathan R Polimeni 1 , Himanshu Bhat 3 , Bruce R Rosen 1 , David A Boas 1 , and Lawrence L Wald 1
1
Department of Radiology, A.A. Martinos
Center for Biomedical Imaging, MGH, Harvard Medical
School, Boston, MA, United States,
2
Department
of Medicine, University of Rome Tor Vergata, Rome,
Italy,
3
Siemens
Medical Solutions, Boston, MA, United States
The aim of this work was to develop novel MRI-indicators
that evaluate cerebrovascular compliance through direct
measures of blood volume changes. We employed
time-of-flight EPI-MRI, and constrained the sequence
parameters to produce MRI-contrast dependent primarily
on blood volume changes. A pulsatility-Volume-Index
(pVI) was defined as the ratio of the signal during
systole divided by the signal during diastole integrated
within the vascular tree. pV1 was on average ~1.5 in
larger cerebral arteries, and varied within each
arterial segment and across arteries. pVI seems to be a
promising MRI-indicator for the evaluation of
cerebrovascular compliance in a highly localized and
subject-specific-manner.
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