Abstract #4101
The Role of Multiparametric MRI in Contemporary Radiotherapy of Prostate Cancer
Radka Stoyanova 1 , Andres Parra 1 , Kyle Padgett 1 , Matthew Abramowitz 1 , and Alan Pollack 1
1
Radiation Oncology, University of Miami,
Miami, Florida, United States
Three clinical trials are initiated for targeted
radiation treatment of prostate cancer, based on the
hypothesis that: (i) the dominant lesions recognized on
multiparametric MRI (MP-MRI) determine outcome; (ii)
MP-MRI-directed biopsies are critical to accurately
assessing pre-treatment (pre-Tx) histopathologic and
molecular characteristics; (iii) MP-MRI parameters are
related to tumor response and molecular abnormalities;
(iv) early MP-MRI changes after treatment will correlate
with response and (v) targeting these lesions will
improve control rates without increasing toxicity. The
workflow for integration of MP-MRI at multiple points in
the trails design is discussed, together with
preliminary results.
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