Abstract #4100
Hybrid PET/MRI of Prostate Cancer: Comparison of Kinetic Activity Of 18F-FDG and Gadolinium-Chelate Using Simultaneous Multimodality Dynamic Imaging
Andrew B Rosenkrantz 1 , Anne-Kristin Vahle 1 , Christian Geppert 2 , Christopher Glielmi 2 , Kent P Friedman 1 , Rachel M Bartlett 1 , Samir S Taneja 3 , Yu-Shin Ding 1 , and Thomas Koesters 1
1
Center for Advanced Imaging Innovation and
Research, Department of Radiology, NYU Langone Medical
Center, New York, NY, United States,
2
Siemens
Healthcare, Erlangen, Germany,
3
Urologic
Oncology, NYU Langone Medical Center, New York, New
York, United States
By providing truly simultaneous spatial and temporal
acquisitions, hybrid PET/MRI using dynamic PET imaging
allows robust comparison of the kinetics of MRI and PET
tracers. In this study, 12 prostate cancer patients
underwent hybrid PET/MRI with simultaneous DCE-MRI and
dynamic PET acquisitions following consecutive
injections of gadolinium-chelate and 18F-FDG. Early
post-injection PET data was reconstructed using
30-second bins, and ROIs were placed on lesions using
fused DCE-MRI/PET images to generate matching
time-activity-curves. Versus gadolinium-chelate, FDG
exhibited significantly later time-to-peak and greater
maximal slope of uptake. Such kinetic differences
between the two agents have not been previously reported
to our knowledge.
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