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Abstract #4100

Hybrid PET/MRI of Prostate Cancer: Comparison of Kinetic Activity Of 18F-FDG and Gadolinium-Chelate Using Simultaneous Multimodality Dynamic Imaging

Andrew B Rosenkrantz 1 , Anne-Kristin Vahle 1 , Christian Geppert 2 , Christopher Glielmi 2 , Kent P Friedman 1 , Rachel M Bartlett 1 , Samir S Taneja 3 , Yu-Shin Ding 1 , and Thomas Koesters 1

1 Center for Advanced Imaging Innovation and Research, Department of Radiology, NYU Langone Medical Center, New York, NY, United States, 2 Siemens Healthcare, Erlangen, Germany, 3 Urologic Oncology, NYU Langone Medical Center, New York, New York, United States

By providing truly simultaneous spatial and temporal acquisitions, hybrid PET/MRI using dynamic PET imaging allows robust comparison of the kinetics of MRI and PET tracers. In this study, 12 prostate cancer patients underwent hybrid PET/MRI with simultaneous DCE-MRI and dynamic PET acquisitions following consecutive injections of gadolinium-chelate and 18F-FDG. Early post-injection PET data was reconstructed using 30-second bins, and ROIs were placed on lesions using fused DCE-MRI/PET images to generate matching time-activity-curves. Versus gadolinium-chelate, FDG exhibited significantly later time-to-peak and greater maximal slope of uptake. Such kinetic differences between the two agents have not been previously reported to our knowledge.

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