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Abstract #4051

Metabolite profiling of glioblastoma stem-like cells with 1 H NMR identifies -aminoadipic acid, product of the activity of aldehyde dehydrogenase ALDH7A1, as putative biomarker of tumor aggressiveness

Sveva Grande 1 , Alessandra Palma 1 , Antonella Rosi 1 , Anna Maria Luciani 1 , Mauro Biffoni 2 , Lucia Ricci-Vitiani 2 , Daniele Runci 2 , Roberto Pallini 3 , Laura Guidoni 4 , and Vincenza Viti 4

1 Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanit and INFN Sanit Group, Roma, Italy, Italy, 2 Dipartimento di Ematologia, Oncologia e Medicina Molecolare, Istituto Superiore di Sanit, Italy, Italy, 3 Dipartimento di Neurochirurgia, Universit Cattolica del Sacro Cuore, Roma, Italy, Italy, 4 INFN Sanit Group, Roma, Italy, Italy

High recurrence rate and failure of conventional treatments in patients with glioblastoma multiforme is attributed to the presence of stem-like cells in these tumors. A dramatic accumulation of α-aminoadipate (αAAD) has been detected in some glioblastoma stem-like cells derived from primary Glioblastoma grade IV by means of 1H NMR and it was related to tumor aggressiveness.. The study suggests a role of αAAD as biomarker of cancer. Expression and high activity of ALDH7A1 could be envisaged in these cells. The indication that, similarly to prostate cancer, ALDH7A1 activity in glioblastoma may correlate with tumour invasiveness, is of potential diagnostic importance.

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