Abstract #4051
Metabolite profiling of glioblastoma stem-like cells with 1 H NMR identifies -aminoadipic acid, product of the activity of aldehyde dehydrogenase ALDH7A1, as putative biomarker of tumor aggressiveness
Sveva Grande 1 , Alessandra Palma 1 , Antonella Rosi 1 , Anna Maria Luciani 1 , Mauro Biffoni 2 , Lucia Ricci-Vitiani 2 , Daniele Runci 2 , Roberto Pallini 3 , Laura Guidoni 4 , and Vincenza Viti 4
1
Dipartimento di Tecnologie e Salute,
Istituto Superiore di Sanit and INFN Sanit Group,
Roma, Italy, Italy,
2
Dipartimento
di Ematologia, Oncologia e Medicina Molecolare, Istituto
Superiore di Sanit, Italy, Italy,
3
Dipartimento
di Neurochirurgia, Universit Cattolica del Sacro Cuore,
Roma, Italy, Italy,
4
INFN Sanit Group, Roma,
Italy, Italy
High recurrence rate and failure of conventional
treatments in patients with glioblastoma multiforme is
attributed to the presence of stem-like cells in these
tumors. A dramatic accumulation of α-aminoadipate (αAAD)
has been detected in some glioblastoma stem-like cells
derived from primary Glioblastoma grade IV by means of
1H NMR and it was related to tumor aggressiveness.. The
study suggests a role of αAAD as biomarker of cancer.
Expression and high activity of ALDH7A1 could be
envisaged in these cells. The indication that, similarly
to prostate cancer, ALDH7A1 activity in glioblastoma may
correlate with tumour invasiveness, is of potential
diagnostic importance.
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