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Abstract #4052

Magnetic resonance metabolic profiling of breast cancer tissue obtained with core needle biopsy for predicting pathologic response to neoadjuvant chemotherapy

Ji Soo Choi 1 , Hyeon-Man Baek 2 , Suhkmann Kim 3 , Min Jung Kim 4 , Hee Jung Moon 4 , and Eun-Kyung Kim 4

1 Samsung Medical Center, Seoul, Seoul, Korea, 2 Korea Basic Science Institute, Chungbuk, Korea, 3 Pusan National University, Busan, Korea, 4 Yonsei University College of Medicine, Seoul, Korea

We performed metabolic profiling of 37 core needle biopsy samples collected from locally advanced breast cancer before neoadjuvant chemotherapy (NAC) using HR-MAS MRS. Various metabolites including choline-containing compounds were identified and quantified by HR-MAS MRS in all tissue samples. In multivariate analysis, the OPLS-DA models built with HR-MAS MR metabolic profiles showed visible discrimination between the pathologic response groups. This study showed OPLS-DA multivariate analysis using metabolic profiles of pretreatment CNB samples assessed by HR- MAS MRS may be used to predict pathologic response before NAC.

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