Abstract #4050
Acquired resistance to EGFR tyrosine kinase inhibitors in human head and neck squamous carcinoma cells (HNSCC) and xenografts is associated with an altered metabolic phenotype
Mounia Beloueche-Babari 1 , Carol Box 2 , Harry G Parkes 1 , Melanie Valenti 2 , Alexis De Haven Brandon2 2 , Liz Jackson 1 , Vaitha Arunan 1 , Sue Eccles 2 , and Martin O Leach 1
1
CRUK & EPSRC Cancer Imaging Centre,
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
2
CRUK
Cancer Therapeutics Unit, Institute of Cancer Research,
Sutton, Surrey, United Kingdom
Acquired resistance to molecular therapeutics, including
tyrosine kinase inhibitors (TKIs), is a key challenge in
personalized cancer medicine. Identifying mechanisms and
biomarkers of resistance could help detect patient
relapse early and improve disease management. Here we
show that acquired resistance to multiple epidermal
growth factor receptor (EGFR) TKIs in human head and
neck squamous cell carcinoma is associated with altered
glycolytic, choline phospholipid and amino acid
metabolism as detected by 1H MRS of cell line and
xenograft tumor extracts. Such effects could provide
potential metabolic imaging biomarkers of acquired
resistance to EGFR TKIs
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