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Abstract #4035

Multimodal fitting of diffusion MRI data for assessing the inflammatory/microvascularity relationship in a glioma rat model

Blanca Lizarbe 1 , Ana Amor-Lpez 1 , Sebastin Cerdn 1 , and Pilar Lpez-Larrubia 1

1 Instituto Investigaciones Biomdicas "Alberto Sols" CSIC-UAM, Madrid, Madrid, Spain

Brain tumors are associated with tissue inflammation and microvasculature alterations that are MRI detectable. DWI and PWI techniques have been widely used to provide information about blood flow/volume, edema and cellularity. Nevertheless, a better understanding of the relationship between inflammation and microvascular changes during tumoral growth needs to be established. In this work, we present a multimodal evaluation of gliobastoma growth in rat brains using DWI with high and low b-weightings, and three models of diffusion with or without perfusion effects- fitting. Our results indicate lower water diffusion behavior but higher perfusion contributions in the early stages of tumor growth.

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