Abstract #4036
Understanding the Heterogeneity of Brain Metastases from Breast Cancer: Lessons from New Models and Experimental Magnetic Resonance Imaging
Donna Murrell 1,2 , Robbert van Gorkum 1 , Amanda Hamilton 1 , Christiane Mallett 1 , Brunilde Gril 3 , Ann Chambers 2,4 , Patricia Steeg 3 , and Paula Foster 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Medical
Biophysics, Western University, London, Ontario, Canada,
3
National
Cancer Institute, Maryland, United States,
4
London
Regional Cancer Program, London, Ontario, Canada
Few preclinical models exist to study HER2+ brain
metastatic breast cancer. Here, we employ MRI techniques
and correlative histology to characterize three murine
models of HER2+ brain metastatic breast cancer
(SUM190-BR3, JIMT1-BR3, 231BR-HER2). We use 3D
anatomical MRI of the mouse brain to illustrate the
incidence, distribution and size of brain metastases and
contrast-enhanced MRI that provides information about
the integrity of the blood-tumour barrier (BTB). Our
findings reflect the substantial heterogeneity of this
disease; understanding the imaging appearance and
underlying biology of these tumours is vital to early
diagnosis and advancements in treatment strategies.
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