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Abstract #4034

Application of prospective cardio-respiratory gating for simultaneous quantitative DCE-MRI of multiple mammary tumours in the mouse.

Veerle Kersemans 1 , Philip D Allen 1 , John S Beech 1 , Stuart Gilchrist 1 , Paul Kinchesh 1 , and Sean C Smart 1

1 Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, United Kingdom

The application of prospective cardio-respiratory gating for quantitative DCE-MRI of abdominal and thoracic tumours was investigated. The method was made feasible through the use of cardio-respiratory synchronisation techniques in conjunction with RF calibrations and accurate temporal sampling. As a result, multiple chest tumours which are highly susceptible to motion corruption during DCE-MRI protocols could be screened simultaneously and classified using quantitative DCE-MRI parameters in a manner that is compatible with high-throughput operation. Moreover, volume imaging permitted visualisation and analysis of multiple breast tumours in the chest during the same acquisition, avoiding operator dependent slice pre-selection errors.

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