Meeting Banner
Abstract #4030

Mn-enhanced MRI for early tumor detection and in vivo growth rate analysis in a mouse medulloblastoma model

Giselle A. Suero-Abreu 1,2 , G. Praveen Raju 3 , Orlando Aristizabal 1 , Eugenia Volkova 1 , Edward J. Houston 1 , Diane Pham 3 , Alexandre Wojcinski 4 , Kamila U. Szulc 1 , Daniel Colon 1 , Alexandra L. Joyner 4 , and Daniel H. Turnbull 1,2

1 Skirball Institute of Biomolecular Medicine, NYU School of Medicine, NY, NY, United States, 2 Department of Radiology, NYU School of Medicine, NY, NY, United States, 3 Department of Pediatrics, Weill Cornell Medical College, NY, NY, United States, 4 Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, NY, NY, United States

Mouse models of medulloblastoma have led to important new insights into the etiology of this common malignant pediatric brain tumor. In the current study, Mn-enhanced MRI (MEMRI) was used to characterize tumor progression in mice with a conditional knockout of Ptch1, a mouse model of sporadic medulloblastoma. 3D MEMRI enabled early detection of pre-neoplastic lesions (validated by histology), and longitudinal MEMRI was used to quantify tumor progression in individual mice. Measured tumor growth rates were heterogeneous, leading to the interesting future potential of MEMRI for guiding histological and micro-array analyses of molecular differences between fast and slow progressing medulloblastomas.

This abstract and the presentation materials are available to members only; a login is required.

Join Here