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Abstract #4031

Intratracheal administration of ultra-small Gd-based nanoparticles: a new protocol for brain tumor targeting

Andrea Bianchi 1 , Damien Moncelet 1 , Franois Lux 2 , Emeline Julie Ribot 1 , Nawal Tassali 1 , Veronique Bouchaud 1 , Olivier Tillement 2 , Pierre Voisin 1 , and Yannick Crmillieux 1

1 Centre de Rsonance Magntique des Systmes Biologiques, Universit Bordeaux Segalen, Bordeaux, Bordeaux, France, 2 Institut Lumire Matire, Universit Claude Bernard, Lyon, France

Glioblastoma is the most aggressive, common and lethal brain tumor. In this context, new noninvasive methods for early detection and therapy are needed in order to improve the prognosis of this pathology. We present here an in vivo MRI longitudinal study of brain cancer detection in tumor-bearing immunodeficient mice through intratracheally- and intravenously- administered multimodal Ultra-Small Rigid Platforms. In this study we showed for the first time that the synergic employment of a strongly T1-weighted MRI UTE sequence and intratracheally-administered gadolinium-based nanoparticles allow the high-precision detection of brain tumor and of its contours.

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