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Abstract #4029

35Cl and 23Na MRI of 9L rat glioma at 21.1 T

Victor D. Schepkin 1 , Malathy Elumalai 2 , Jason Kitchen 3 , Chunqi Qian 4 , Peter Gor'kov 1 , and William Brey 1

1 CIMAR, NHMFL/FSU, Tallahassee, FL, United States, 2 AMRIS, NHMFL/UF, Gainesville, FL, United States, 3 CIMAR, NHMFL/FSU, Tallahassee, Florida, United States, 4 NINDS/NIH, Bethesda, MD, United States

Chloride is a unique window for investigating brain function and cancer development. The in vivo challenges of low sensitivity, short T2 relaxation time and the small size of the acquisition matrix were evaluated here. The experiments in normal rat brain and glioma revealed: chloride in vivo is as visible as the sodium MR signal. However, the bi-exponential FID and limited sampling size dramatically affect the quantification of images and needs to be corrected according to the developed Matlab model. The finding of increased chloride concentration in glioma correlates with the hypothesis stating a critical role of chloride for tumor progression.

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