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Abstract #3979

Imaging and visualization of cardiac muscle microstructure in rats using high-resolution MRI

Silun Wang 1 , Xulei Qin 2 , Xiaodong Zhang 1 , Mary B. Wagner 3 , and Baowei Fei 2,4

1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2 Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 3 Department of Pediatrics, Emory University, Atlanta, GA, United States, 4 Biomedical Engineering, Emory University, GA, United States

We analyze the cardiac muscle microstructural characteristics in rats using SWI and DTI imaging. SWI provided useful information to explore the anatomical characteristics of cardiac muscle, including left ventricle and papillary muscle and the cardiac vascular system in rats. DTI cardiac muscle tractography identified the orientation and distributions of cardiac muscle fibers. The current results are potentially useful to monitor cardiac muscle pathology including ischemia induced cardiac muscle damage and abnormal iron deposit as well as evaluations of treatment effects.

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