Abstract #3978
Myocardial fibrosis by CMR LGE in a large cohort of pediatric thalassemia major patients
Antonella Meloni 1 , Maddalena Casale 2 , Aldo Filosa 2 , Rosellina Rosso 3 , Antonino Vallone 4 , Gianluca Valeri 5 , Daniele De Marchi 1 , Vincenzo Positano 1 , Massimo Lombardi 1 , and Alessia Pepe 1
1
CMR Unit, Fondazione G.Monasterio
CNR-Regione Toscana and Institute of Clinical
Physiology, Pisa, Italy,
2
UOSD
Centro per le Microcitemie, AORN Cardarelli, Napoli,
Italy,
3
U.O.
Talassemie ed Emoglobinopatie, Ospedale Ferrarotto CT
Az. Osp. Universitaria Policlinico Vittorio Emanuele,
Catania, Italy,
4
Istituto di Radiologia, Az.
Osp. "Garibaldi" Presidio Ospedaliero Nesima, Catania,
Italy,
5
Dipartimento
di Radiologia, Azienda Ospedaliero-Universitaria
Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona,
Italy
In pediatric patients with thalassemia major myocardial
fibrosis is not a rare finding to keep in mind in the
cardiological management. When appropriate treatment has
been administered since early childhood, CMR LGE can be
postponed until 13 years of age. By the natural history
of this large cohort of pediatric patients where HCV
infection has been appropriately prevented, myocardial
fibrosis seems to be associated with cardiac iron and
high cardiac output.
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