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Abstract #3974

Noninvasive assessment of cardiomyocyte breadth from extracellular volume fraction with MRI

Shi-Jun Zhang 1 , Jiyang Jin 1 , Min Chen 1 , Lin Wang 1 , Andreas Greiser 2 , and Shenghong Ju 1

1 Department of Radiology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, China, 2 Siemens AG Healthcare Sector, Bayern, Germany

The myocardial extracellular volume fraction (ECV) is a reflection of the relative volume of the extracellular space and cells in myocardium, and we infer that the size of the cardiomyocytes affects ECV and in the other hand could be reflected by ECV. We found through the present study of swine that ECV correlates negatively with cardiomyocyte breadth under physiological conditions, indicating ECV might be a potential MRI biomarker for cardiomyocyte size estimation in vivo.

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