Abstract #3973
Microstructural Characterization of the Infarct Border Zone in Humans with In Vivo Diffusion Tensor MRI and Gray-Zone Late Gadolinium Enhancement
Choukri Mekkaoui 1 , Christian T Stoeck 2 , Marcel P Jackowski 3 , Timothy G Reese 4 , Sebastian Kozerke 5 , and David E Sosnovik 6
1
Harvard Medical School - Massachusetts
General Hospital, Boston, MA, United States,
2
University
and ETH Zurich, zurich, Switzerland,
3
University
of So Paulo, So Paulo, Brazil,
4
Athinoula
A Martinos center for Biomedical imaging, Boston, United
States,
5
University
and ETH Zurich, Zurich, Switzerland,
6
Harvard
Medical School - Massachusetts General Hospital, Boston,
United States
The infarct border zone plays a major role in the
development of mechanical and electrical dysfunction
during post-infarction remodeling. We used in vivo
diffusion tensor MRI (DTI) and late gadolinium
enhancement (LGE) in patients with recent myocardial
infarctions to examine the properties of the infarct
border zone. We show that an increase in LGE in the
border zone of just 1 standard deviation above normal is
associated with significant microstructural abnormality,
including marked heterogeneity of myofiber tract
orientation and loss of tract coherence.
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